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Objective To evaluate the prospective association between childhood abuse experiences and depressive symptoms in adolescence.Methods Students in grade 3 and 4'from three primary schools were selected,with informed consent,through convenience cluster sampling in Bengbu,Anhui province in May 2013.The students' body height,weight were assessed.Childhood abuse experiences including emotional,physical or sexual abuses,as well as depressive symptoms were reported by children themselves.Data on parental educational background and household economic status were collected through parent questionnaire.A follow up was conducted 4 years later after baseline survey.Depressive symptoms were evaluated by using Children's Depression Inventory at baseline survey,and by using Mood and Feeling Questionnaire at follow-up.Logistic regression model was used to analyze the relationship between childhood abuse experiences and depressive symptoms in adolescence.Results A total of 1 172 students were included in baseline survey,and a follow-up was conducted for 87.1％ of them (n=1 021).Among 1 126 students with complete information on childhood abuse experiences at baseline survey,the reported rates of physical,emotional and sexual abuses were 12.8％ (144/1 126),11.1％ (125/1 126) and 10.9％ (123/1 126),respectively.The prevalence of depressive symptoms at baseline survey and follow-up was 7.0％ (82/1 172) and 12.3％ (126/1 021),respectively.After adjusted for baseline depressive sympto ms,age at follow-up,sex,the only-child in family,household economic status,divorce of parents and BMI,childhood emotional and physical abuse experiences were significant risk factors for depressive symptoms in mid-adolescence,with the ORs were 1.86 (95％CI:1.03-3.36,P=0.039) and 2.37 (95％CI:1.39-4.03,P=0.001),respectively.Conclusion Childhood physical and emotional abuse might increase the risk of depressive symptoms in adolescence.
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Objective To explore the developmental characteristics of circadian rhythms in hypothalamus-pituitary-adrenal (HPA) axis during puberty.Methods A total of 1 070 students from Grade 2-3 in 3 primary schools in Ma'anshan city,Anhui province,were selected for physical examination and circadian rhythm of HPA axis checked from 2015 to 2017.Saliva samples were collected at each of the following three time points:immediately upon wakening,30 minutes after wakening and bedtime,with the index of circadian rhythm of HPA axis calculated,which including cortisol awake response (CAR),cortisol in puberty priming and diurnal cortisol slope (DCS).Testicular volume,palpation and visual inspection of breast development were used to assess the state of purbety development on boys and girls.Information on gender,date of birth,time to fall asleep,wake-up time and weekly physical activity were gathered through questionnaire survey.Nonparametric test was used to compare the differences of baseline,follow-up period and different adolescent developmental processes of each index on circadian rhythm of HPA axis.Results During the period of follow-up program and comparing with the continuous undeveloped group,CAR and the changes of CAR showed significantly increase,both in the puberty priming group and continuous development group,with statistically significant differences (CAR:Z=8.551,4.680,respectively;P＜0.01;the changes of CAR:Z=4.079,2.700,respectively,P＜0.01).There were no significant differences noticed in CAR and the changes of CAR between puberty priming group or continuous development group.The area under the curve (AUC) of cortisol in puberty priming group was slightly higher than that in the persistent undeveloped group (Z=2.591,P=0.010).Both the changes of daily cortisol slope (DCS) in puberty priming group and continuing developed group decreased significantly,when comparing with those in continuous undeveloped group (Z=2.450,Z=2.151;all P＜0.05).There was no significant difference noticed in the changes of cortisol in puberty priming and DCS between different puberty development stages (the changes ofAUC:x2=2.747,P=0.253;DCS:x2=4.554,P=0.032).Conclusions The indexes of circadian rhythm of HPA axis were associated with the development of puberty.Both the cortisol awakening response and the total amount of diurnal cortisol secretion showed an increase,along with the puberty development.The change of diurnal cortisol slope declined with the development of puberty.
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Objective To evaluate the prospective association between childhood abuse experiences and depressive symptoms in adolescence.Methods Students in grade 3 and 4'from three primary schools were selected,with informed consent,through convenience cluster sampling in Bengbu,Anhui province in May 2013.The students' body height,weight were assessed.Childhood abuse experiences including emotional,physical or sexual abuses,as well as depressive symptoms were reported by children themselves.Data on parental educational background and household economic status were collected through parent questionnaire.A follow up was conducted 4 years later after baseline survey.Depressive symptoms were evaluated by using Children's Depression Inventory at baseline survey,and by using Mood and Feeling Questionnaire at follow-up.Logistic regression model was used to analyze the relationship between childhood abuse experiences and depressive symptoms in adolescence.Results A total of 1 172 students were included in baseline survey,and a follow-up was conducted for 87.1％ of them (n=1 021).Among 1 126 students with complete information on childhood abuse experiences at baseline survey,the reported rates of physical,emotional and sexual abuses were 12.8％ (144/1 126),11.1％ (125/1 126) and 10.9％ (123/1 126),respectively.The prevalence of depressive symptoms at baseline survey and follow-up was 7.0％ (82/1 172) and 12.3％ (126/1 021),respectively.After adjusted for baseline depressive sympto ms,age at follow-up,sex,the only-child in family,household economic status,divorce of parents and BMI,childhood emotional and physical abuse experiences were significant risk factors for depressive symptoms in mid-adolescence,with the ORs were 1.86 (95％CI:1.03-3.36,P=0.039) and 2.37 (95％CI:1.39-4.03,P=0.001),respectively.Conclusion Childhood physical and emotional abuse might increase the risk of depressive symptoms in adolescence.
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Objective To explore the developmental characteristics of circadian rhythms in hypothalamus-pituitary-adrenal (HPA) axis during puberty.Methods A total of 1 070 students from Grade 2-3 in 3 primary schools in Ma'anshan city,Anhui province,were selected for physical examination and circadian rhythm of HPA axis checked from 2015 to 2017.Saliva samples were collected at each of the following three time points:immediately upon wakening,30 minutes after wakening and bedtime,with the index of circadian rhythm of HPA axis calculated,which including cortisol awake response (CAR),cortisol in puberty priming and diurnal cortisol slope (DCS).Testicular volume,palpation and visual inspection of breast development were used to assess the state of purbety development on boys and girls.Information on gender,date of birth,time to fall asleep,wake-up time and weekly physical activity were gathered through questionnaire survey.Nonparametric test was used to compare the differences of baseline,follow-up period and different adolescent developmental processes of each index on circadian rhythm of HPA axis.Results During the period of follow-up program and comparing with the continuous undeveloped group,CAR and the changes of CAR showed significantly increase,both in the puberty priming group and continuous development group,with statistically significant differences (CAR:Z=8.551,4.680,respectively;P＜0.01;the changes of CAR:Z=4.079,2.700,respectively,P＜0.01).There were no significant differences noticed in CAR and the changes of CAR between puberty priming group or continuous development group.The area under the curve (AUC) of cortisol in puberty priming group was slightly higher than that in the persistent undeveloped group (Z=2.591,P=0.010).Both the changes of daily cortisol slope (DCS) in puberty priming group and continuing developed group decreased significantly,when comparing with those in continuous undeveloped group (Z=2.450,Z=2.151;all P＜0.05).There was no significant difference noticed in the changes of cortisol in puberty priming and DCS between different puberty development stages (the changes ofAUC:x2=2.747,P=0.253;DCS:x2=4.554,P=0.032).Conclusions The indexes of circadian rhythm of HPA axis were associated with the development of puberty.Both the cortisol awakening response and the total amount of diurnal cortisol secretion showed an increase,along with the puberty development.The change of diurnal cortisol slope declined with the development of puberty.
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Objective@#To determine the possible relations between hair cortisol concentration (HCC) as a biomarker of chronic stress and childhood overweight and obesity.@*Methods@#Children from grade 1 to 3 from 2 primary schools in Bengbu were invited to participate in the study; and those who suffer from mental disorders, endocrine diseases and those who took hormone drugs were excluded. Parental questionnaire was implemented to collect information on physical activity, screen time, sleep duration, sugar-beverage consumption, as well as socio-economic status. Height and weight were examined. Eligible hair samples from 1 263 children (598 boys and 665 girls) were obtained, and the cortisol content was determined. Multivariate logistic regression model analysis was recruited to examine the association between HCC quartiles and overweight and obesity among boys and girls, respectively.@*Results@#HCC in P50 (P25-P75) among girls and boys was separately 11.86 (10.57-13.15) and 11.71 (10.54-13.09) µg/kg (Z=-0.886, P=0.376); HCC in P50 (P25-P75) among non-overweight, overweight and obesity boys was separately 11.62 (10.45-12.82), 12.24 (10.88-13.55) and 12.30 (10.99-13.53) µg/kg (χ2=8.24, P=0.016); HCC in P50 (P25-P75) among non-overweight, overweight and obesity girls was separately 11.35 (10.06-12.62), 12.07 (11.04-13.21) and 12.59 (11.12-13.63) µg/kg (χ2=36.16, P<0.001). After age, physical activity, screen time, sleep duration, sugared beverages and socio-economic status adjusted, compared with HCC in Q1 level, girls whose HCC in Q2, Q3 Q4 level had higher rates in overweight, with OR (95%CI) at 1.10 (1.04-3.32), 2.59 (1.51-4.45) and 3.16 (1.79-5.57), respectively. Girls with HCC in Q3 and Q4 level had higher rates in obesity, with OR (95%CI) at 2.22 (1.16-4.26) and 5.62 (3.04-10.41). Among boys, highest quartiles in HCC was risk factor for overweight, OR (95%CI) was 2.14 (1.18-3.90).@*Conclusion@#Hair cortisol had a significant relation with overweight and obesity in 6-9 years old childhood especially among girls.
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During an individual's life, puberty is not only a crucial phase for physical development, but a key period for neuroendocrine transformation. As a major neuroendocrine axis, the influence of hypothalamic-pituitary-adrenal (HPA) axis's changes during puberty on mental and physical health, as well as emotional symptoms, is causing a growing attention. However, information of its developing pattern and circadian variation is limited. Recent research has demonstrated that certain developing pattern of HPA axis in puberty is closely related to the adolescent emotional disorders, which highlights the recognition of HPA functions developing paths under both resting and stress state and the evaluation of its prediction effect for the adolescent emotional disorders. Generally, cortisol awakening response is utilised to assess HPA functions. Elaborating the variation of HPA axis functions from the puberty to the later developing process provides much guiding significance for the early screening, intervention and treatment of adolescent emotional disorders.
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Objective@#To determine possible relations between early adiposity rebound and adolescent development.@*Methods@#Prospective children cohort from 2 kindergartens selected through clustering convenience sampling method in Anhui Province was established since Sep. 2010. Participants were classified as Cohort 1 (2010), Cohort 2 (2011) and Cohort 3 (2012) according to the recruiting year. Till Sep. 2015, a toal of 802 girls were included in this study, and received follow-up till primary school. During kindergarten period, physical examination was carried out every 3 months, 8 times in total. In primary school, physical examination was carried out annually; till Sep.2015, the cohort 1, 2, 3 took physical examination for 12, 11, 10 times, respectively. Information on household economic status and child physical activity was acquired through parents questionnaire survey, and breast development were assessed through visual inspection and palpation. Adiposity rebound was determined according to Rolland-Cachera's method for each girl. Differences between early adiposity rebound and normal adiposity rebound groups were compared by using t test and χ2 test. Multivariate regression analysis was applied to explore the association between early adiposity rebound and breast development.@*Results@#The average age of participants was (8.90±0.87) years old and the BMI was (17.48±2.70) kg/m2. The average age at adiposity rebound was (6.16±0.90) years old and the BMI was (15.33±1.82) kg/m2. Premature breast development was found significantly higher in girls in early adiposity rebound group (27.8%, 54/802) than it in normal adiposity rebound group (13.7%) (P<0.001). After current adiposity, age, household economic status, childhood physical activity adjusted, the OR of premature beast development in early adiposity rebound group was 2.41(95%CI: 1.41-4.12).@*Conclusion@#Early adiposity rebound increases the risk of premature puberty in girls.